The word stress comes from the Latin word "stringere" which means to bind tightly. The development of the concept of stress begins in the 14th century. Regardless of the numerous definitions of stress, it is about the reaction of each individual to stressful life events that depend on the characteristics of the individual's personality, developed defense mechanisms, social factors, and motivation. In this paper, stress and sources of stress (stressors) are analyzed in detail. The analysis of stressors showed how stress affects physical and mental health. In the first part of the paper, stress in general, types of stress reactions, causes of stress and effects of stress in different professions were discussed. The activities that should be carried out by the manager of the organization in order to reduce the causes of stress in the organization, as well as the training of employees to successfully cope with and overcome stress, were also analyzed. The first part of the work is completed with an analysis of job satisfaction and the factors that influence job satisfaction. In the second part, research was done on the impact of stress on job satisfaction. The survey questionnaire was addressed to private and public sector employees in order to compare which stressors affect employee satisfaction in the public sector and which in the private sector. It was expected that the results of the private sector respondents would differ significantly from the results of the public sector respondents, given that the private sector has greater financial opportunities that could be directed to activities for prevention, management and overcoming stress, improving working conditions, redistributing work to avoid overcapacity and similarly, however, the analysis of the obtained results showed that the job satisfaction of employees in the private and public sector is the same.